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Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes

CompletedNA

Sponsor: University Hospital, Lille

Conditions: Parkinson's Disease, Amyotrophic Lateral Sclerosis, Oxidative Stress, Iron Overload

Interventions: deferiprone, placebo

Countries: France

Peripheral blood mononuclear cells (PBMC) and platelets could be interesting ex vivo models to study brain diseases. Indeed, there is no access to neurons from patients. However, PBMC can exhibit different physiopathological mechanisms that are ubiquitous (i.e. oxidative stress, mitochondriopathy with energy metabolism, inflammation, protein folding, iron metabolism and programmed cell death ...). The platelets are pivotal in the healing system with large range of growth factors. A new therapeutic concept of conservative iron chelation with deferiprone for neuroprotection is under development. The action of deferiprone on the different mechanisms and notably the oxidative stress are to obtain from a collection of PBMC and platelets from patient having Parkinson's disease and Amyotrophic lateral sclerosis and healthy controls to study ex vivo. PBMC and platelets will be stored for future analyses.

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Parkinson's disease according to Movement Disorders Society criteria
* Amyotrophic Lateral Sclerosis according to El escorial criteria
* Age and sex matched healthy controls

Exclusion Criteria:

* Severe comorbidities (cancer, other degenerative diseases, hemopathy, inflammatory diseases)

Locations (1)

Lille, France