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Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

RecruitingNA

Sponsor: Centre Hospitalier Universitaire, Amiens

Conditions: Alzheimer Disease

Interventions: Brain MRI, neuropsychological evaluation, Blood

Countries: France

In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

Eligibility overview

Sex: ALL

Age: 40 Years to 85 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Patients

* Age between 40 and 85
* French mother tongue
* Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
* MCI, according to Albert et al.'s criteria (Albert et al., 2011)
* Mild dementia (MMSE\>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
* Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
* Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
* Social security coverage
* Healthy controls

* Healthy age and gender matched volunteers will be recruited into the study from the general population.

Exclusion Criteria:

* Reading or writing difficulties related to a learning disorder or illiteracy.
* A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):

* NYHA stage IV dyspnoea.
* respiratory impairment requiring oxygen therapy.
* liver impairment.
* kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
* Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:

* stroke.
* meningitis or encephalitis.
* severe head injury.
* sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
* epilepsy (requiring ongoing treatment),
* psychiatric disorders (other than treated depression).
* treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
* Impossibility to perform a neuropsychological evaluation or brain MRI.
* Withdrawal from the study at any time, if desired.
* Pregnancy
* Contra-indication to MRI:

* nerve stimulators
* cochlear implants
* ferromagnetic foreign bodies close to nervous structures in the eye or brain
* cerebral shunts
* dental appliances
* Legal guardianship or incarceration.

Locations (1)

Amiens, France