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Online Program to Reduce Depression in MS

CompletedNA

Sponsor: Charite University, Berlin, Germany

Conditions: Multiple Sclerosis

Interventions: Deprexis, DeprexisPlus

Countries: United States, Germany

This is an international, multicenter, randomized controlled trial of an internet-based CBT intervention for depression (Deprexis) conducted in five MS centers in the US and Germany. The trial consists of a three-arm primary trial phase and an extension phase targeted at maintenance.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion criteria

* age \> 18
* neurologist-confirmed diagnosis of MS (all forms)
* self-reported depressive symptoms (BDI-Fastscreen \> 4)
* fluent in German or English (depending on study site),
* willingness to engage in self-administration of an iCBT intervention for 3 months and complete follow-up
* ability to travel to the outpatient center for two clinical assessments (baseline and month 3)
* internet access at home

Exclusion criteria:

* unwilling or unable to consent,
* diagnosis of bipolar or psychosis (as determined by M.I.N.I structured interview),
* substantial neurocognitive impairments such as dementia or autism
* moderate or high risk of suicide (according to MINI module C) or by clinical impression
* very severe depression that would interfere with the ability to participate in the study (based on clinical judgment by the physician at the recruitment site).
* current psychotherapy/behavioral treatments for depression
* started pharmacotherapy for depression within the last 2 months
* MS relapse or steroid treatment in the last 4 weeks
* concurrent participation in another clinical trial that includes an intervention
* refusal to saving, processing and forwarding of pseudonymized data

Locations (5)

Los Angeles, California, United States
Kansas City, Kansas, United States
State College, Pennsylvania, United States
Hamburg, Free and Hanseatic City of Hamburg, Germany
Berlin, State of Berlin, Germany