NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

Bronchial Thermoplasty for Severe Asthma With Dynamic Hyperinflation

CompletedNA

Sponsor: University Hospital, Toulouse

Conditions: Asthma, Hyperinflation

Interventions: Bronchial thermoplasty for treatment of severe asthma

Countries: France

Bronchial thermoplasty is a treatment for severe asthma that consist in decreasing the thickness of bronchial muscle by heat using a catheter inserted into the bronchi under direct vision with the help of an endoscope This treatment has shown efficacy on symptoms, quality of life and the number of exacerbations related to severe asthma. This clinical study evaluates the efficiency of this treatment on the dynamic hyperinflation phenomenon (worsening of bronchial obstruction during exercise in patients with asthma contributing to worsening shortness of breath).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Severe asthma, uncontrolled despite optimal treatment according to GINA (global initiative for asthma) recommendations
* At least 2 exacerbations treated by systemic steroids in the last year
* FEV1 between 40 and 80% of predicted values and dynamic hyperinflation (defined as a decrease in inspiratory capacity by more than 500 ml during exercise)

Exclusion Criteria:

* Current asthma exacerbation or respiratory infection
* History of exacerbation after bronchoscopy
* FEV1 \< 40% of predicted values
* Oxygen saturation \< 90%
* Contra-indications to ALAIR catheter system : pacemaker or other electronic implanted device
* Allergy to Remifentanyl or Propofol
* pregnancy; breastfeeding

Locations (1)

Toulouse, Midi Pyrenees, France