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Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis

TerminatedNA

Sponsor: University Hospital, Montpellier

Conditions: Progressive Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting

Interventions: Neuropsychological assessment, Neurologic consultation, MRIs (with vasoreactivity testing)

Countries: France

The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs and the Diffusion Tensor Imaging , and correlate these differences with Clinical disability and cognitive disorder results.

Eligibility overview

Sex: ALL

Age: 30 Years to 50 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria :

* For Both patients and healthy volunteers :
* Age limits ≥ 30 et ≤ 50 years
* Subject able to understand the nature, the aim and the methodology of the study.
* Collection of the informed consent
* Affiliation or recipient with the mode of social security.
* For the patients :
* Suffering from progressive multiple sclerosis (primary progressive forms or secondary progressive forms) OR
* Suffering from relapsing-remitting multiple sclerosis

Exclusion Criteria :

* For Both patients and healthy volunteers :
* Systemic pathology with neurological manifestations
* Antecedent of psychiatric disorders including psychosis (Except anxious depressive disorder)
* Subject presenting contraindications in MRI (Ferromagnetic foreign bodies, pace-maker)
* Claustrophobia
* Women pregnant or Breast-feeding
* Person with majority age protected by the law (supervision, trusteeship or under safeguard of justice).
* Subject unable to understand the nature and the aim of the study and/or communication difficulties with investigator
* Antecedent of serious cranial trauma (according to classification) of ischaemic stroke ou intracranial hematoma.
* For the patients :
* Antecedent of serious cranial trauma (according to classification), anterior or evolutive neurologic disease other than multiple sclerosis
* Recent relapse of multiple sclerosis
* For the healthy volunteers :
* Antecedent of serious cranial trauma (according to classification), anterior or evolutive neurologic disease
* Antecedent of neurological disease
* In period of exclusion relative to another protocol or which the annual amount of the allowances maximum of 4500 € was reached.

Locations (1)

Montpellier, France