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Effects of Stimulation Patterns of Deep Brain Stimulation

Enrolling By InvitationNA

Sponsor: Duke University

Conditions: Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia

Interventions: Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns

Countries: United States

The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.

Eligibility overview

Sex: ALL

Age: 21 Years to 80 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS)
* Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery
* Neurologically stable
* Able to understand the study and consent form

Exclusion Criteria:

* Inability to execute the motor tasks during the study
* Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
* Clinically ineffective DBS

Locations (3)

Gainesville, Florida, United States
Atlanta, Georgia, United States
Durham, North Carolina, United States