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A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

NCT02247479

TerminatedPhase 3

Sponsor: Hoffmann-La Roche

Conditions: Geographic Atrophy

Interventions: Lampalizumab, Sham

Countries: United States, Argentina, Australia, Austria, Belgium, Canada, Denmark, France

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled study evaluating the efficacy and safety of lampalizumab administered by intravitreal injections in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

Eligibility overview

Sex: ALL

Age: 50 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Well demarcated area(s) of Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD) with no evidence of prior or active choroidal neovascularization (CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria: Study Eye

* History of vitrectomy surgery, submacular surgery, or other surgical intervention for AMD
* Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein occlusion, and proliferative diabetic retinopathy
* Previous intravitreal drug delivery (intravitreal corticosteroid injection, anti-angiogenic drugs, anti-complement agents, or device implantation) Ocular Exclusion Criteria: Both Eyes
* GA in either eye due to causes other than AMD
* Previous treatment with eculizumab, lampalizumab and/or fenretinide
Locations (145)
  • Birmingham, Alabama, United States
  • Phoenix, Arizona, United States
  • Tucson, Arizona, United States
  • Bakersfield, California, United States
  • Beverly Hills, California, United States
  • Irvine, California, United States
  • Los Angeles, California, United States
  • Oakland, California, United States
  • Palm Desert, California, United States
  • San Francisco, California, United States
  • San Francisco, California, United States
  • Santa Ana, California, United States
  • Santa Barbara, California, United States
  • Boynton Beach, Florida, United States
  • Fort Myers, Florida, United States
  • Melbourne, Florida, United States
  • Palm Beach Gardens, Florida, United States
  • Palm Beach Gardens, Florida, United States
  • Pensacola, Florida, United States
  • Plantation, Florida, United States
  • St. Petersburg, Florida, United States
  • Tallahassee, Florida, United States
  • Tampa, Florida, United States
  • Augusta, Georgia, United States
  • Marietta, Georgia, United States
  • ‘Aiea, Hawaii, United States
  • Chicago, Illinois, United States
  • Oak Forest, Illinois, United States
  • Indianapolis, Indiana, United States
  • West Des Moines, Iowa, United States
  • + 115 more on CT.gov