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Inclusion Criteria:

* Healthy male and surgically sterile or post-menopausal female participants 18-55 years of age
* Body mass index (BMI) between 18 to 32 kilograms per meter-squared (kg/m\^2)
* Non-smoking participants and former smoking participants (who have not smoked for the past six months before first dosing)
* Male participants and their partners of child-bearing potential must be willing to use two effective contraceptive methods as defined by protocol
* Willing to abstain from xanthine-containing beverages and food (coffee, tea, cola, chocolate, and "energy drinks") from 72 hours prior to Day -1 through the study
* Willing to abstain from grapefruit, pomelo, star fruit or Seville orange containing products from day 7 prior study start until study end
* Willing to avoid prolonged sun exposure while taking RO5424802 and through follow-up

Exclusion Criteria:

* Pregnant or lactating women, men with female partners who are pregnant or lactating, or women of child bearing potential
* Clinically significant abnormalities on physical examination, vital signs, or laboratory test results during screening or prior to admission to the study unit
* Positive test for drugs of abuse, alcohol or cotinine test at screening or prior to admission to the study unit or suspicion of regular consumption of drug(s) of abuse
* History of recent alcohol consumption exceeding 2 standard drinks per day on average. Alcohol consuming is prohibited from 72 hours prior to study start until the end of the study
* Participants with any risk factors or family history for QT/QTcF and electrocardiogram (ECG) abnormalities
* A history of any concurrent clinically significant hematologic, renal, hepatic, pulmonary, neurological, psychiatric, allergies, gastrointestinal, metabolic or endocrine disorder, or cardiovascular disease or infections
* Positive screening test for hepatitis B, C, or human immunodeficiency virus (HIV)
* Use of any medications (prescriptions or over-the-counter), within 2 weeks or 5 half-lives (whichever is longer) before the first dose of study medication with exception of acetaminophen up to 2 grams (g) per day up to 48 hours prior to dosing, not to exceed 4 g total during the week prior to dosing
* Routine or chronic use of more than 2 g of acetaminophen daily
* Use of any herbal supplements (for example, St. John's Wort) or any metabolic inducers within 4 weeks or 5 half-lives (whichever is longer) before the first dose of study medication, including but not limited to the following drugs: rifampin, rifabutin, glucocorticoids, carbamazepine, phenytoin, and phenobarbital
* Strenuous activity, sunbathing or contact sports are not allowed from 4 days prior to study start until the end of the study
* Participation in an investigational drug or device study within 45 days or 5 half-lives (whichever time period is longer), or 6 months for biologic therapies, prior to first dosing
* Donation of blood over 450 milliliters (mL) within 45 days prior to screening

• Austin, Texas, United States