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Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis Criterion

NCT02043964

CompletedNA

Sponsor: Lille Catholic University

Conditions: Clinically Isolated Syndrome, Multiple Sclerosis

Interventions: tears and cerebrospinal fluid sampling

Countries: France

This is a multicentric and prospective study for the validation of a diagnostic method in multiple sclerosis. Our hypothesis is that there is a characteristic profile of tears that can be recognized in order to help in the diagnosis of this pathology and that could possibly replace the lumbar punction which is an invasive method. Semi-automatic and automatic techniques of isoelectric focusing will be developed for analyzing data from tears. These results will help in the identification of markers of this disease.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* 18 years old or more
* Clinically isolated syndrome of less than 3 months of onset
* Informed consent to participate

Exclusion Criteria:

* Progressive primary multiple sclerosis
* Relapsing remitting multiple sclerosis
* Persons wearing contact lenses
* Ocular Infection
* Corticoid treatment at least 30 days before sampling
* Immunosuppressive or immunomodulatory treatment at least 3 months before sampling
* Pregnancy or breast feeding
* No coverage by the Social Insurance

Locations (15)

Bordeaux, France
Caen, France
Clermont-Ferrand, France
Dijon, France
Lille, France
Lomme, France
Lyon, France
Marseille, France
Nancy, France
Nantes, France
Nice, France
Poissy, France
Rouen, France
Strasbourg, France
Valenciennes, France