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Tear Analysis in the Diagnosis of Multiple Sclerosis

NCT02016222

TerminatedNA

Sponsor: Lille Catholic University

Conditions: Primary Progressive Multiple Sclerosis

Interventions: tears sampling

Countries: France

In the primary progressive multiple sclerosis, the detection of oligoclonal bands in cerebrospinal fluid is critical for the diagnosis. However, lumbar puncture for cerebrospinal fluid collection is considered relatively invasive. Our hypothesis is that oligoclonal bands detection in tears is possible and useful for the diagnosis of multiple sclerosis.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* 18 years old or more
* Progressive neurological deficit after 12 months
* At least 9 T2 brain lesions of minimum 3 mm evidenced by MRI and/or four or more T2 lesions of minimum 3 mm with positive Visual Evoked Potential and/or positive spinal cord MRI (at least two focal T2 lesions)

Exclusion Criteria:

* Asiatic persons
* recurrent forms of the disease
* Persons wearing contact lenses
* Ocular Infection
* Corticoid treatment at least 30 days before sampling
* immunosuppressive or immunomodulatory treatment 3 months before sampling

Locations (13)

Nice, Alpes Maritimes, France
Lille, Nord, France
Bordeaux, France
Caen, France
Clermont-Ferrand, France
Dijon, France
Lille, France
Lyon, France
Marseille, France
Nancy, France
Nîmes, France
Poissy, France
Strasbourg, France