NCT lookup
Pull any trial record directly from ClinicalTrials.gov.
Sponsor: University Hospital, Clermont-Ferrand
Conditions: Asbestos-exposed Workers
Interventions: New algorithm called VeoTM (General Electric Healthcare, Milwaukee, MI, USA)
Countries: France
Asbestos fibers were intensively used throughout the 20th century and remain prevalent in developing countries. However, asbestos exposure induces a variety of benign and malignant pleural and lung diseases. The most common asbestos-induced neoplasm is lung cancer. Moreover, thin-section computed tomography (CT) is more sensitive than a chest x-ray for detecting early asbestos-related conditions. Increased exposure to radiation underpins the consequences of cancer induction. However, reducing CT doses increases image noise from the filtered back projection (FBP) reconstruction. Strategies to reduce radiation exposure include the use of iterative reconstruction algorithms. A new algorithm called VeoTM (General Electric Healthcare, Milwaukee, MI, USA) decreases the image noise up to 70% compared with the gold standard FBP model. Moreover, Veo improves spatial resolution with excellent detection of low and high contrast objects from a CT Dose Index (CTDIvol) equal to 0.3 mGy. The objective of the present study is to compare Veo with the gold standard FBP for detecting pulmonary asbestos-related conditions among workers previously exposed to asbestos. Comparisons included radiation delivered and image quality.
Sex: ALL
Age: 18 Years to 90 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * asbestos-exposed workers * ability to give a written informed consent Exclusion Criteria: * \- previous history of cancer * previous history of thoracic surgery * other interstitial pathology known
- Clermont-Ferrand, France