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Sponsor: ANRS, Emerging Infectious Diseases
Conditions: Hiv Infection
Interventions: A peripheral blood sample
Countries: France
Short title : X-linked biological response to HIV sensing: the ANRS EP 53 study. Main outcome : To demonstrate that HIV-infected women carry the TLR7 c.32A\>T SNP at a higher frequency than uninfected women, arguing in favor of a role of impaired production of IFN-alpha by pDCs in the risk of becoming infected by HIV-1. Secondary outcome : To directly demonstrate at a single cell level that the TLR7 c.32A\>T SNP is responsible for a reduce production of IFN-alpha by pDCs after activation of TLR7 by HIV-1 RNA. Short abstract (public dissemination) : Male and female display some differences in how their immune system responds to pathogens. This could be related to hormonal or genetic factors located on the X chromosome. This project aims at characterizing X-linked factors that can influence the innate immune response to HIV-1.
Sex: FEMALE
Age: 18 Years to —
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: 1. Caucasian Female 2. HIV-1 infection (ELISA and western-blot tests) 3. HIV-infection through the sexual route before 50 years-old 4. Continuous antiretroviral therapy for more than 6 months 5. Plasma HIV-1 RNA \<50 copies/ml in the last 6 months 6. Age \>18-year old 7. Health insurance 8. Informed consent Exclusion Criteria: 1. HIV-infection through vertical or parenteral routes 2. Chronic infectious disease, notably HCV infection (hepatitis C virus) 3. Acute infectious disease 4. Auto-immune disease 5. Absence of social security (health insurance) 6. Pregnant or breastfeeding woman 7. Incapable adult
- Toulouse, France