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The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'

CompletedN/A

Sponsor: Imperial College London

Conditions: HIV Positive, Ageing

Countries: Ireland, United Kingdom

The purpose of this study is to identify medical conditions that may cause particular problems to individuals receiving care for HIV infection over the age of 50. In addition, as the effects and potentially the side effects, of HIV medication may change with age, this study will also investigate the association between age and differing effects of antiretroviral therapies such as treatment outcomes, side effects and the levels of drugs in blood. Results from this study may inform future HIV treatment guidelines on how individuals with HIV infection are monitored. The results may also assist in the design of future studies for the treatment of diseases associated with ageing.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

Older HIV-positive cohort (n=1000):

* documented HIV infection
* age \>50 years at study entry
* self defined white or black African ethnicity
* likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African
* able to comprehend study patient information leaflet

  -Younger HIV-positive cohort (n=500):
* documented HIV infection
* age \<50 at study entry\*
* self defined white or black African ethnicity
* likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African.
* able to comprehend study patient information leaflet

  * this group will comprise of at least 150 subjects in each of the following age groups: 20-29, 30-39, 40-49 years. Recruitment will be monitored by the Study Monitoring Team.

HIV-negative cohort (n=500):

* documented negative HIV test at screening
* age \>50 years at study entry
* self defined white or black African ethnicity
* registered with a General Practitioner and gives permission for contact with that General Practitioner.

Exclusion Criteria:

* in the opinion of the investigator, those unable or unwilling to comply with the requirements of the study
* life expectancy less than 6 months

Locations (8)

Dublin, Ireland
Brighton, Sussex, United Kingdom
London, United Kingdom
London, United Kingdom
London, United Kingdom
London, United Kingdom
London, United Kingdom
London, United Kingdom