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Inclusion Criteria:

* HER2-positive disease determined locally
* Histologically or cytologically confirmed invasive breast cancer
* Prior treatment for breast cancer in the adjuvant, unresectable, locally advanced or metastatic setting must include both chemotherapy, alone or in combination with another agent, and an anti-HER2 agent, alone or in combination with another agent
* Documented progression of incurable, unresectable, LABC, or mBC, defined by the investigator: progression must occur during or after most recent treatment for LABC/mBC or within 6 months of completing adjuvant therapy
* Measurable and/or non-measurable disease
* Left ventricular ejection fraction (LVEF) \>/=50% by either echocardiogram (ECHO) or multiple-gated acquisition scan (MUGA)
* Eastern Cooperative Oncology Group (ECOG) performance status of 0,1 or 2
* Adequate organ function
* Use of highly effective contraception as defined by the protocol

Exclusion Criteria:

* History of treatment with trastuzumab emtansine
* Prior enrollment into a clinical study containing trastuzumab emtansine regardless of having received trastuzumab emtansine or not
* Peripheral neuropathy of Grade \>/= 3 per National Cancer Institute (NCI) common terminology criteria for adverse events (CTCAE) v 4.0
* History of other malignancy within the previous 5 years, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage 1 uterine cancer, synchronous or previously diagnosed HER2-positive breast cancer
* History of receiving any anti-cancer drug/biologic or investigational treatment within 21 days prior to first study treatment except hormone therapy, which can be given up to 7 days prior to first study treatment; recovery of treatment-related toxicity consistent with other eligibility criteria
* History of exposure to cumulative doses of anthracyclines
* History of radiation therapy within 14 days of first study treatment. The participant must have recovered from any resulting acute toxicity (to Grade \</=1) prior to first study treatment.
* Metastatic central nervous system (CNS) disease only
* Brain metastases which are symptomatic
* History of a decrease in LVEF to less than (\<) 40% or symptomatic congestive heart failure (CHF) with previous trastuzumab treatment
* History of symptomatic CHF (New York Heart Association \[NYHA\] Classes II-IV) or serious cardiac arrhythmia requiring treatment
* History of myocardial infarction or unstable angina within 6 months of first study treatment
* Current dyspnea at rest due to complications of advanced malignancy or requirement for continuous oxygen therapy
* Current severe, uncontrolled systemic disease (clinically significant cardiovascular, pulmonary, or metabolic disease)
* Pregnancy or lactation
* Currently known active infection with human immunodeficiency virus (HIV), hepatitis B virus, or hepatitis C virus
* History of intolerance (such as Grade 3-4 infusion reaction) or hypersensitivity to trastuzumab or murine proteins or any component of the product

• Buenos Aires, Argentina
• La Rioja, Argentina
• Mar del Plata, Argentina
• North Sydney, New South Wales, Australia
• Waratah, New South Wales, Australia
• Westmead, New South Wales, Australia
• South Brisbane, Queensland, Australia
• Kurralta Park, South Australia, Australia
• Melbourne, Victoria, Australia
• St Albans, Victoria, Australia
• Murdoch, Western Australia, Australia
• Salzburg, Austria
• Vienna, Austria
• Vienna, Austria
• Anderlecht, Belgium
• Brussels, Belgium
• Brussels, Belgium
• Charleroi, Belgium
• Edegem, Belgium
• Ghent, Belgium
• Leuven, Belgium
• Liège, Belgium
• Namur, Belgium
• Wilrijk, Belgium
• Rio de Janeiro, Rio de Janeiro, Brazil
• Porto Alegre, Rio Grande do Sul, Brazil
• Florianópolis, Santa Catarina, Brazil
• São Paulo, São Paulo, Brazil
• São Paulo, São Paulo, Brazil
• Sofia, Bulgaria
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