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Vascular Subphenotypes of Lung Disease in HIV & COPD

CompletedN/A

Sponsor: University of Pittsburgh

Conditions: Pulmonary Artery Hypertension

Countries: United States

This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Male/Female 18-80 years of age.
* Subject has been previously enrolled in PACT/MAC/ECRC study.
* Must have recent ProBNP test \>120pg/ml or abnormal echocardiogram (right ventricular systolic pressure \>or=40mmHg) without evidence of left sided heart failure.

Exclusion Criteria:

* Previous diagnosis of congenital heart failure.
* If evidence of Left ventricular systolic or diastolic dysfunction, echo will be reviewed by the PI on a case by case basis.
* Creatine clearance \<60ml/min per 1.73 m2.
* Undiagnosed chest pain or myocardial infarction, stroke or cardiovascular event within 3 months.
* Pregnancy.
* Subjects receiving chronic anticoagulant.
* Inability to complete the 6 minute walk test.

Locations (1)

Pittsburgh, Pennsylvania, United States