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Impact of Immediate Versus South African Recommendations Guided ART Initiation on HIV Incidence

CompletedNA

Sponsor: ANRS, Emerging Infectious Diseases

Conditions: HIV Infection

Interventions: Immediate ARV treatment initiation with TDF/FTC/EFV, South African recommendation guided ARV (TDF/FTC/EFV) initiation

Countries: South Africa

This trial is evaluating a public health intervention strategy trial which aims to reduce the incidence of HIV at a population-level. The proposed strategy is a two steps process: * Extensive HIV counselling and testing, and comprehensive prevention programme among a target population * Immediate ART initiation after HIV diagnosis, irrespective of CD4 count criteria. The underlaying trial hypothesis is that HIV testing followed by immediate ART initiation of all HIV-infected individuals will prevent onward transmission and reduce HIV incidence in the population. This is a cluster randomised controlled trial with a total of 22 communities used as the units for randomisation. Enrolment of a population of 22 000 individuals among which 4 400 are expected to be HIV-Infected.

Eligibility overview

Sex: ALL

Age: 16 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Aged 16 and more
* Member of a household in the designated cluster within the Hlabisa sub-district of KwaZulu Natal in South Africa
* Able and willing to give written informed consent for trial participation and/or HIV counselling and testing

Locations (1)

Hlabisa, KwaZulu-Natal, South Africa