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Simplified Insulin Protocol Using Lantus in Elderly

CompletedPhase 4

Sponsor: Joslin Diabetes Center

Conditions: Diabetes

Interventions: Glargine

Countries: United States

The purpose of this study is to find out if simplifying your diabetes treatment by decreasing number of insulin injections, with the help of a long acting insulin called glargine, can decrease the episodes of low blood glucose.

Eligibility overview

Sex: ALL

Age: 70 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age 70 years or older
* Diagnosis of diabetes mellitus Type II
* At least 2 (short-acting or mixed) insulin injections per day
* At least 1 episode of hypoglycemia (glucose value \<70) on screening CGM

Exclusion Criteria:

* Patients with the following illnesses in the past 12 months Myocardial infarction Angina Coronary artery bypass grafting Percutaneous transluminal coronary angiography Cerebrovascular event (stroke, TIA)
* Active liver disease (history of cirrhosis or LFT \> 3 times normal)
* On dialysis or with severe renal dysfunction (creatinine clearance \<20 ml/min)
* Malignancy that limits life span to less than 18 months
* Patients seen in the geriatric clinic who already have simplified regimen as proposed in the study

Locations (1)

Boston, Massachusetts, United States