NCT lookup

Inclusion Criteria:

* Pathologically verified primary central nervous system lymphoma No prior PCNSL treatment.
* Patients treated with steroids alone are eligible
* No signs of lymphoma outside the CNS
* ECOG performance status 0-4
* Age \> 17 and \< 76 years
* Written informed consent from the patient or guardian

Exclusion Criteria:

* Cardiac failure \> 3
* Pregnancy or lactation. Women of childbearing potential are requested to use an effective method of contraception to avoid pregnancy for a period from entry to the study and at least 3 months after the last study medication
* Previous malignancy unless disease free for at least five years
* Active infection.
* Regarding tuberculosis, patients at risk should be tested for latent TB according local practice at each treating centre.
* Positive HIV status
* Organ transplantation
* Serious psychiatric illness
* Prior radiotherapy to the brain
* Concomitant anti-inflammatory medication that cannot be discontinued
* Creatinine clearance \< 60 ml/minute calculated by Cockcroft and Gault formula
* Peripheral blood count with granulocytes \<1.5 x 109L or platelets \< 100 x 109L
* Serum bilirubin \>1.5 times or ASAT and alkaline phosphatase \>2 times upper limits of normal.
* Known anaphylaxis or IgE-mediated hypersensitivity to murine protein or any component of Rituximab excludes patients from Rituximab treatment, but not from the remaining part of the study

• Aarhus, Denmark