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Evaluation of Degree of Conversion of HER2 Receptor Between Primary Breast Cancer and Metastasis
Evaluation of Degree of Conversion of HER2 Receptor Between Primary Breast Cancer and Metastasis

NCT01377363

CompletedN/A

Sponsor: Spanish Breast Cancer Research Group

Conditions: Breast Cancer

Countries: Spain

This is a Prospective Clinical Trial without drugs, to determine the HER2 status in the metastasis of patients with primary breast cancer HER2. 32 Sites have been taking part in this Clinical Trial.

Eligibility overview

Sex: FEMALE

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria
Inclusion Criteria:

* Patients who have given their written informed consent to participate in the study.
* Women over 18 years.
* Breast cancer locally recurrent or metastatic at first relapse or after successive progressions.
* Patient has to have available a sample of the primary tumor in paraffin.
* Patients who are planning for the next 6 weeks, the biopsy (fine needle aspiration / drainage of fluid cavities, open biopsy, core biopsy) of locally recurrent or metastatic lesion \[local relapse in the chest wall, nodal , cutaneous or subcutaneous metastases, peripheral lymph nodes and other soft tissues accessible, bone metastases, visceral metastases (lung, liver, brain, etc..) or pleural effusion / ascites / pericardial / cerebrospinal\] according to clinical practice center.

Exclusion Criteria:

* Patients with cognitive impairment that might impede a proper understanding of the written informed consent, according to medical criteria.
* Ipsilateral breast local relapses or contralateral breast away.
* Patients diagnosed with a second neoplasm, with the exception of cervical carcinoma in situ and non-melanoma skin carcinoma treated properly.
Locations (32)
  • Alcoy, Alicante, Spain
  • Elda, Alicante, Spain
  • Palma de Mallorca, Balearic Islands, Spain
  • Manresa, Barcelona, Spain
  • Castellon, Castellón, Spain
  • Algeciras, Cádiz, Spain
  • Jerez de la Frontera, Cádiz, Spain
  • A Coruña, La Coruña, Spain
  • Las Palmas de Gran Canaria, Las Palmas, Spain
  • Alcorcón, Madrid, Spain
  • Leganés, Madrid, Spain
  • Pozuelo de Alarcón, Madrid, Spain
  • Santa Cruz de Tenerife, Tenerife, Spain
  • Sagunto, Valencia, Spain
  • Barcelona, Spain
  • Barcelona, Spain
  • Cáceres, Spain
  • Girona, Spain
  • Granada, Spain
  • Granada, Spain
  • Guadalajara, Spain
  • Madrid, Spain
  • Madrid, Spain
  • Murcia, Spain
  • Seville, Spain
  • Toledo, Spain
  • Valencia, Spain
  • Valencia, Spain
  • Valencia, Spain
  • Valencia, Spain
  • + 2 more on CT.gov