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Lung HIV Disease in a Large Cohort-Pitt

CompletedN/A

Sponsor: University of Pittsburgh

Conditions: Pulmonary Disease, HIV, Emphysema

Countries: United States

HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected patients, and it has been hypothesized that this accelerated disease progression is the result of one or more latent infections that amplifies the pulmonary inflammatory response. The investigators will examine the prevalence and progression of emphysema in subjects with and without HIV and determine risk factors for emphysema in this population.

Eligibility overview

Sex: MALE

Age: 18 Years to 72 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Age 18 years old or older
* By participant's report, s/he is:
* HIV positive OR
* HIV negative and at high risk
* Recruited via:
* Pitt Men's Study/MAC
* Women's Interagency Health Study
* Attendee of UPMC HIV/AIDS Program

Exclusion Criteria:

* Acute onset of shortness of breath, cough, fever or heart condition such as tachycardia, angina or arrhythmias
* Pregnancy
* MI, CVA or cardiovascular event within last 3 months
* Eye or abdominal surgery with last 3 months
* Active TB by documentation or self-report
* Weight \> 500 lbs.
* Exposure to \> 10 rads in the previous 12 months (i.e., 2 CT or 4 cardiac cath…or other fluoroscopic exams For bronchoscopy subjects only
* Subjects with an upper or lower respiratory tract infection
* Individuals with a Primary diagnosis of vocal cord dysfunction, or those with significant or uncontrolled systemic diseases will be excluded
* 75 years of age or older

Locations (2)

Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States