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Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia

CompletedPhase 4

Sponsor: HealthPartners Institute

Conditions: Hyperglycemia

Interventions: NPH insulin plus Complete Insulin Orders, Complete Insulin Orders

Countries: United States

The objective of this study is to determine the best insulin regimen for hospitalized patients who receive high doses of steroids who have high blood glucose.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Men or women aged ≥18 years who receive steroids in doses greater than physiologic replacement levels of ≥ 10 mg Prednisone or its equivalent of dexamethasone or methylprednisolone.
* Have signed the consent form for the study
* Have a BG \> 180 mg/dL any time during the first 24 hour of steroid administration that is above physiological replacement ( ≥ 10 mg Prednisone or equivalent)
* Are scheduled to be in hospital ≥ 2 days.

Exclusion Criteria:

* Unable to read or understand English
* History of psychiatric disability affecting informed consent or compliance with drug intake
* Type 1 diabetes
* Acute or chronic renal failure (creatinine clearance \< 30 mL/min estimated by method of Cockcroft and Gault)
* Patients in Hospice Care
* Age \<18 years
* Previously enrolled in this study.
* Not appropriate for the steroid protocol in judgment of the principal investigator and/or attending physician.

Locations (1)

Saint Louis Park, Minnesota, United States