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A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis

NCT01094262

TerminatedPhase 2

Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Conditions: Osteoarthritis, Osteoarthritis, Knee, Pain, Arthralgia, Joint Pain

Interventions: Oxycodone CR (standard pain medication), JNJ-42160443, JNJ-42160443, Placebo

Countries: United States, Canada

The purpose of this study is to evaluate pain relief, safety, and tolerability of a new treatment (JNJ-42160443) for moderate to severe pain of osteoarthritis of the knee in comparison to a standard pain treatment and placebo.

Eligibility overview

Sex: ALL

Age: 40 Years to 80 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Clinical diagnosis of osteoarthritis of the knee
* Have moderate to severe pain based on a trial questionnaire
* Must be on a stable dose of pain medication for 4 weeks before entering the trial
* Medically stable condition

Exclusion Criteria:

* History of joint replacement surgery in the affected joint or planned surgery involving the affected joint during the trial
* Diabetes mellitus
* Uncontrolled cardiovascular disease or hypertension
* Previous treatment with another investigational NGF inhibitor therapy
Locations (44)
  • Tucson, Arizona, United States
  • Carmichael, California, United States
  • Pismo Beach, California, United States
  • Clearwater, Florida, United States
  • Hallandale, Florida, United States
  • Oldsmar, Florida, United States
  • St. Petersburg, Florida, United States
  • Tampa, Florida, United States
  • Marietta, Georgia, United States
  • Perry, Georgia, United States
  • Woodstock, Georgia, United States
  • Boise, Idaho, United States
  • Eagle, Idaho, United States
  • Avon, Indiana, United States
  • Evansville, Indiana, United States
  • Baton Rouge, Louisiana, United States
  • Mandeville, Louisiana, United States
  • Metairie, Louisiana, United States
  • New Orleans, Louisiana, United States
  • Shreveport, Louisiana, United States
  • Watertown, Massachusetts, United States
  • St Louis, Missouri, United States
  • Omaha, Nebraska, United States
  • Mamaroneck, New York, United States
  • Williamsville, New York, United States
  • Greenville, North Carolina, United States
  • Raleigh, North Carolina, United States
  • Kettering, Ohio, United States
  • Oklahoma City, Oklahoma, United States
  • Collegeville, Pennsylvania, United States
  • + 14 more on CT.gov