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Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer
Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer

NCT01081951

Active Not RecruitingPhase 2

Sponsor: AstraZeneca

Conditions: Ovarian Cancer

Interventions: olaparib, paclitaxel, carboplatin, paclitaxel, Drug: carboplatin

Countries: United States, Australia, Belgium, Canada, Czechia, Germany, Italy, Japan

To compare the efficacy of olaparib in combination with paclitaxel and carboplatin (AUC4) when compared with carboplatin (AUC6) and paclitaxel alone in patients with advanced ovarian cancer.

Eligibility overview

Sex: FEMALE

Age: 18 Years to 125 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Diagnosed with serous ovarian cancer
* Patients who have received no more than 3 previous platinum containing treatments and were progression free for at least 6 months following the end of the last platinum treatment
* At least one lesion that is suitable for accurate repeated measurements

Exclusion Criteria:

* Patients receiving any systemic anticancer chemotherapy, radiotherapy (except palliative) within two weeks from the last dose prior to study treatment
* Hypersensitivity to pre medications required for treatment with paclitaxel/carboplatin
Locations (53)
  • Stanford, California, United States
  • West Hollywood, California, United States
  • Orlando, Florida, United States
  • Indianapolis, Indiana, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • New York, New York, United States
  • Portland, Oregon, United States
  • Parkville, Australia
  • Randwick, Australia
  • Brussels, Belgium
  • Leuven, Belgium
  • Namur, Belgium
  • Wilrijk, Belgium
  • Vancouver, British Columbia, Canada
  • Hamilton, Ontario, Canada
  • Toronto, Ontario, Canada
  • Toronto, Ontario, Canada
  • Québec, Quebec, Canada
  • Sherbrooke, Quebec, Canada
  • Brno, Czechia
  • Brno, Czechia
  • Hradec Králové, Czechia
  • Olomouc, Czechia
  • Prague, Czechia
  • Essen, Germany
  • Frankfurt, Germany
  • Hamburg, Germany
  • München, Germany
  • Solingen, Germany
  • + 23 more on CT.gov