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Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of ACT-128800 in Patients With Relapsing-remitting Multiple Sclerosis
Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of ACT-128800 in Patients With Relapsing-remitting Multiple Sclerosis

NCT01006265

CompletedPhase 2

Sponsor: Actelion

Conditions: Multiple Sclerosis

Interventions: ACT-128800 Dose 1, Placebo, ACT-128800 Dose 2, ACT-128800 Dose 3

Countries: United States, Australia, Austria, Belgium, Bulgaria, Canada, Czechia, Finland

This study will assess the efficacy, safety, and tolerability of ACT-128800 in patients with relapsing-remitting multiple sclerosis.

Eligibility overview

Sex: ALL

Age: 18 Years to 55 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Adult males and females
* Diagnosis of RRMS as defined by the revised (2005) McDonald Diagnostic Criteria for Multiple Sclerosis (MS).
* Signed inform consent prior to initiation of any study-mandated procedure.

Exclusion Criteria:

* A diagnosis of MS categorized as primary progressive or secondary progressive or progressive relapsing.
* Patients currently treated for an autoimmune disorder other than MS.
* Contraindications for MRI.
* Ongoing bacterial, viral, or fungal infection.
* History or presence of malignancy.

Additional inclusion and exclusion criteria apply with respect to medical conditions and concomitant treatments which could affect patients' risk from participating in the study.
Locations (115)
  • Scottsdale, Arizona, United States
  • Tucson, Arizona, United States
  • Sacramento, California, United States
  • Stanford, California, United States
  • Sarasota, Florida, United States
  • Indianapolis, Indiana, United States
  • Kansas City, Kansas, United States
  • Lenexa, Kansas, United States
  • Baltimore, Maryland, United States
  • Worcester, Massachusetts, United States
  • St Louis, Missouri, United States
  • Newark, New Jersey, United States
  • Latham, New York, United States
  • New York, New York, United States
  • Schenectady, New York, United States
  • Stony Brook, New York, United States
  • Raleigh, North Carolina, United States
  • Akron, Ohio, United States
  • Cincinnati, Ohio, United States
  • Columbus, Ohio, United States
  • Portland, Oregon, United States
  • Philadelphia, Pennsylvania, United States
  • Burlington, Vermont, United States
  • Richmond, Virginia, United States
  • Kirkland, Washington, United States
  • Fitzroy, Australia
  • Westmead, Australia
  • Amstetten, Austria
  • Sankt Pölten, Austria
  • Vienna, Austria
  • + 85 more on CT.gov