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Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy
Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

NCT01003691

CompletedPhase 1

Sponsor: Pfizer

Conditions: Age-Related Maculopathy, Age-Related Maculopathies, Eye Diseases, Retinal Degeneration, Macular Degeneration

Interventions: RN6G, Placebo

Countries: United States

The purpose of this study is to determine the safety and tolerability of multiple doses of RN6G in subjects with advanced dry, age-related macular degeneration including geographic atrophy.

Eligibility overview

Sex: ALL

Age: 60 Years to 85 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Be of non-child bearing potential
* Diagnosis of dry AMD including uni- or multi-focal geographic atrophy without foveal involvement
* BCVA of 20/50 or better in the study eye

Exclusion Criteria:

* Evidence of ocular disease other than advanced AMD or GA in the study eye
* History or diagnosis of exudative (wet) AMD, with subretinal or choroidal neovascular lesions in the study eye
* Presence of disease or condition that might compromise the cardiovascular, hematological, renal, hepatic, pulmonary, endocrine, central nervous immune, or gastrointestinal system
* Requires ocular or systemic medications that are known to be toxic to the lens, retina or optic nerve
Locations (24)
  • Campbell, California, United States
  • Los Gatos, California, United States
  • San Jose, California, United States
  • San Jose, California, United States
  • San Jose, California, United States
  • Tampa, Florida, United States
  • Tampa, Florida, United States
  • Augusta, Georgia, United States
  • Augusta, Georgia, United States
  • Augusta, Georgia, United States
  • Rochester, New York, United States
  • Rochester, New York, United States
  • West Columbia, South Carolina, United States
  • West Columbia, South Carolina, United States
  • West Columbia, South Carolina, United States
  • West Columbia, South Carolina, United States
  • Abilene, Texas, United States
  • Abilene, Texas, United States
  • Abilene, Texas, United States
  • Abilene, Texas, United States
  • Austin, Texas, United States
  • Austin, Texas, United States
  • Austin, Texas, United States
  • Cedar Park, Texas, United States