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Imaging of Brain Amyloid Plaques in the Aging Population

Enrolling By InvitationPhase 4

Sponsor: Mayo Clinic

Conditions: Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia

Interventions: Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451)

Countries: United States

This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in amyloid burden over time, and concurrent change in clinical status.

Eligibility overview

Sex: ALL

Age: 30 Years to 100 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age 30-100
* Subjects who have completed or are scheduled to undergo the neurological evaluation procedures in the Mayo Clinic Study of Aging, Mayo ADRC, or Mayo neurodegenerative disease clinics.

Exclusion Criteria:

* Subjects unable to lie down without moving for 10 minutes
* Women who are pregnant or cannot stop breast feeding for 24 hours at the time of scanning
* Claustrophobic patients unable to tolerate the scans
* Standard safety exclusionary criteria for MRI such as metallic foreign bodies, pacemaker, etc.

Locations (1)

Rochester, Minnesota, United States