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Evaluation of Maraviroc Intensification in HIV Infected Patients With Insufficient Immune Restoration

CompletedPhase 2

Sponsor: French National Agency for Research on AIDS and Viral Hepatitis

Conditions: HIV Infection, HIV Infections

Interventions: maraviroc

Countries: France

This pilot study aims to evaluate Maraviroc intensification strategy during 24 weeks in HIV infected patients under efficient (CV\< 50 cp/mL), controlled antiretroviral therapy (≥ 6 months) and uncompleted immune restoration (CD4\<350 cells/mL and CD4 earning \<100 cells/mL during last 24 months). The study will include 60 patients whose follow up is carried out for 48 weeks. recruitment period will be maintained for 12 months.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* HIV-1 infection
* maraviroc-naives patients
* CD4 less than 350 cells/mm3
* viral load less than 50 cp/mL and CD4 earning less than 100 cells/mm3 during last 24 months

Exclusion Criteria:

* HIV-2 infection
* X4 tropism at inclusion
* pregnancy and breast feeding
* interferon, immunomodulatory drugs treatment or anti-HIV vaccines and chemotherapy
* hypersensibility of peanut or soya

Locations (1)

Paris, France