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A Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis
A Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis

NCT00938587

CompletedPhase 2

Sponsor: Pfizer

Conditions: Rheumatoid Arthritis

Interventions: PF-04171327 10 mg, Prednisone Placebo, PF-04171327 25 mg, Prednisone Placebo, Prednisone 5 mg

Countries: United States, Czechia, Hong Kong, Hungary, Russia, Serbia, Singapore, Slovakia

This study will investigate the safety and efficacy of an investigational drug, PF-04171327 on the signs and symptoms of rheumatoid arthritis in patients that require glucocorticoids while on background methotrexate. This study will also look at the response of chemical and biological markers in rheumatoid arthritis patients. Lastly, this study will measure the PK (amount of drug in the blood) of methotrexate while patients may be taking PF-04171327.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Patients ≥ 18 years of age, diagnosed with rheumatoid arthritis for a minimum duration of 3 months
* On stable dose of methotrexate for at least 6 weeks prior to screening
* Patient must have minimum disease activity level of ≥ 6 tender/painful joints, ≥ 6 swollen joints and CRP ≥ 0.7 mg/dL
* Not currently receiving steroid medication

Exclusion Criteria:

* Pregnant or nursing women
* Patients that have active infections, TB, HIV and/or Hepatitis B or C
* Patients that have a history of intolerance or significant adverse effects with the use of glucocorticoids
Locations (41)
  • Anniston, Alabama, United States
  • Anniston, Alabama, United States
  • Daytona Beach, Florida, United States
  • Miami, Florida, United States
  • Ormond Beach, Florida, United States
  • Zephyrhills, Florida, United States
  • Springfield, Illinois, United States
  • Bingham Farms, Michigan, United States
  • Bingham Farms, Michigan, United States
  • Duncansville, Pennsylvania, United States
  • České Budějovice, Czechia
  • Hostivice, Czechia
  • Prague, Czechia
  • Prague, Czechia
  • Praha 11 - Chodov, Czechia
  • New Territories, Hong Kong
  • Békéscsaba, Hungary
  • Budapest, Hungary
  • Debrecen, Hungary
  • Szolnok, Hungary
  • Moscow, Russia
  • Moscow, Russia
  • Saint Petersburg, Russia
  • Smolensk, Russia
  • Belgrade, Serbia
  • Niška Banja, Serbia
  • Singapore, Singapore
  • Piešťany, Slovakia
  • Žilina, Slovakia
  • Seoul, South Korea
  • + 11 more on CT.gov