NCT lookup
Pull any trial record directly from ClinicalTrials.gov.
Sponsor: Loyola University
Conditions: Type 2 Diabetes, Renal Insufficiency
Interventions: 0.5 units/kg daily insulin, 0.25 units/kg daily insulin
Countries: United States
It is imperative to devise easy to follow, yet appropriate, guidelines for insulin use in renal-impaired patients. This will be done by comparing two regimens: 1) glargine once daily plus mealtime glulisine based on weight alone and 2) a predetermined dosing reduction algorithm with glargine/glulisine based on weight with reduction for decreased estimated GFR by MDRD as follows: \< 30 ml/min/1.73m2 or on dialysis reduce dose by 50% from weight based calculation.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Type 2 Diabetes Mellitus of mor than 1year * GFR less than 30 ml/min/1.73m2 or dialysis * Age greater than 18years * Entry blood glucose (fasting or random) greater than 180mg% Exclusion Criteria: * Type 1 Diabetes Mellitus * New onset hyperglycemia * Pregnant * Solid organ transplant within 1 year * Steroids prednisone greater than 7.5mg/day or equivalent * Hospital LOS predicted less than 2 days * Severe liver disease * Known hypopituitarism or adrenal insufficiency * Patients in the ICU * Patients with hypoglycemic unawareness * Outpatient insulin dose less than 0.6 units/kg
- Chicago, Illinois, United States
- Chicago, Illinois, United States
- Maywood, Illinois, United States