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Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients

NCT00863460

UnknownPhase 2

Sponsor: Institut Curie

Conditions: Primary Central Nervous System Lymphoma

Interventions: cranial radiotherapy, intensive chemotherapy and hematopoietic stem cell rescue, MTX based chemotherapy

Countries: France

Purpose of the study : To evaluate the antitumoral effect of two therapeutic procedures and to evaluate their respective toxicity on the CNS.

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Histopathologically or cytologically proven diagnostic of Primary CNS lymphoma
* All histological types of non-Hodgkin's lymphoma, except MALT
* Age \> 18 and \< 60 ans.
* Negative for HIV, HCV and HBV
* Written informed consent -

Exclusion Criteria:

* Age \< 18 or \> 60 ans
* Isolated intra-ocular lymphoma
* Previous history of indolent lymphoma
* Previous chemotherapy or radiotherapy for PCNSL
* Isolated CNS relapse of systemic NHL
* Previous history of cancer in the last 5 years, except basocellular carcinoma and non invasive cervix cancer
* Renal insufficiency or creatinin clearance \< 60 ml/min
* Liver enzymes \> 3N.
* Platelets \< 100 000/mm3 or neutrophils \< 1500/mm3)
* Previous history of organ transplantation or other cause of severe immunodeficiency
* Pregnancy or active sexual women with no contraception
* Unable to follow the protocol for any reason

Locations (23)

Amiens, France
Angers, France
Argenteuil, France
Besançon, France
Bordeaux, France
Clermont-Ferrand, France
Grenoble, France
Lens, France
Limoges, France
Marseille, France
Nantes, France
Nice, France
Nîmes, France
Paris, France
Perpignan, France
Poitiers, France
Reims, France
Rennes, France
Saint-Cloud, France
Saint-Priest-en-Jarez, France
Saint-Quentin, France
Tours, France
Vandœuvre-lès-Nancy, France