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Sponsor: Weill Medical College of Cornell University
Conditions: Obstructive Sleep Apnea
Sleep Apnea is a prevalent condition that has been increasingly diagnosed in the adult population and is now considered an independent risk factor for the development of cardiovascular disease. A better understanding of the mechanisms associated with the development of cardiovascular disease in sleep apnea is needed. This research will investigate the function of the adenosine deaminase (ADA) in subjects with sleep disorders. This enzyme is responsible for metabolizing adenosine, a neuromodulator that is released during periods of sleep apnea and that has been found to promote vascular thrombosis. There are multiple types of ADA that are genetically determined and have different levels of function. Those different forms of this enzyme may determine groups that are more susceptible to the development of thrombosis. Given the known association between sleep apnea and thrombosis, this study will determine if polymorphisms of this enzyme are differentially found in subjects with sleep apnea as compared to other sleep disturbances. The overall objective of this experiment is to assess the presence of ADA polymorphisms in sleep apnea.
Sex: ALL
Age: 21 Years to —
Healthy volunteers: No
Study type: OBSERVATIONAL
Inclusion Criteria: * 21 years or older * Patient of the Weill Cornell Pulmonary Associates and Cornell Center for Sleep Medicine practices * Clinically indicated for an overnight sleep study within six months prior to or after the outpatient office visit Exclusion Criteria: * Pregnancy