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A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

CompletedPhase 1

Sponsor: University of California, Irvine

Conditions: Port Wine Stain

Interventions: Rapamycin Treatment of Port Wine Stain

Countries: United States

The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rapamycin will improve PWS therapeutic outcome.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* port wine stain birthmarks suitable for comparison testing.

Exclusion Criteria:

* Pregnancy.
* Abnormal blood hematology or chemistry blood tests or urine analysis.
* History of cancer, History of high cholesterol, lipids or liver disease
* Allergy to macrolide drugs (e.g., erythromycin).
* Any therapy within the previous two months to the proposed PWS treatment sites.
* Concurrent use of known photosensitizing drugs,immunosuppressive drugs or systemic steroids,antifungals, antiepileptics, HIV protease inhibitors, cimetidine, cisapride, clarithromycin, dannzol, diltiazem, erythromycin, metoclopramide, rifabutin, rifampin, rifapentine, troleandomycin, or verapamil.

Locations (1)

Irvine, California, United States