NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication

CompletedPhase 4

Sponsor: University of Washington

Conditions: Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis

Interventions: Atorvastatin, Niacin, Colesevelam, Placebo Niacin, Placebo Colesevelam

Countries: United States

Atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries. This study will examine the effectiveness of a combination of cholesterol-lowering medications at decreasing the fat content of atherosclerotic deposits in people who have coronary artery disease or carotid artery disease.

Eligibility overview

Sex: ALL

Age: 21 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Clinically established coronary artery disease or carotid artery disease with greater than 15% stenosis by ultrasound
* Family history of cardiovascular disease
* Apolipoprotein B level greater than or equal to 120 mg/dL (LDL level should be between 100 and 190 mg/dL without medication)
* Has been undergoing lipid therapy for no more than 12 months before study entry
* Medically stable
* Medically able to undergo MRI procedure

Exclusion Criteria:

* Uses pacemaker or has metallic implants
* Has immediate plans for carotid endarterectomy
* History of alcohol or drug abuse
* Active liver disease or liver dysfunction, defined by elevations in alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels greater than 1.5 times the upper limit of normal
* Serum creatine kinase (CK) level greater than 3 times the upper limit of normal before study entry
* Serum creatinine level greater than 2.5 times the upper limit of normal
* Diabetes, with a fasting glucose level greater than 150 mg/dL or hemoglobin A1c (HbA1c) level greater than 8% before study entry
* Uncontrolled high blood pressure, defined as average resting systolic blood pressure greater than 200 mm Hg or average resting diastolic blood pressure greater than 95 mm Hg

Locations (4)

Los Angeles, California, United States
Boise, Idaho, United States
Seattle, Washington, United States
Yakima, Washington, United States