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Inclusion Criteria:

* History of completely resected NSCLC and adjuvant/neoadjuvant chemotherapy with platinum-based regimen
* Histologically/cytologically confirmed recurrence of NSCLC after curative therapy with surgery and adjuvant/neoadjuvant chemotherapy
* Must have measurable disease according to RECIST criteria
* ECOG Performance Score of 0-2 determined within 2 weeks prior to enrollment
* Expected survival \> 12 weeks
* Adequate bone marrow function,as evidenced by:

  1. Absolute neutrophil count (ANC) \> 1,500/µL
  2. Platelet count \> 100,000/µL
  3. Hemoglobin \> 8 g/dL (determined within 2 weeks prior to enrollment)
* Adequate renal function evidenced by:

  1. serum creatinine \< 1.5 mg/dL OR
  2. calculated creatinine clearance \>45 mL/min.
* Adequate hepatic function evidenced by:

  1. Serum total bilirubin \< 1.5 mg/dL OR less than the upper limit of normal (ULN)
  2. Alkaline phosphatase \< 3X the ULN for the reference lab (\< 5X the ULN for patients with known hepatic or bony metastases)
  3. SGOT/SGPT \< 3X the ULN for the reference lab (\< 5X the ULN for patients with known hepatic metastases)
* Must be recovered from both acute and late effects of any prior surgery, radiotherapy, other antineoplastic therapy
* Signed informed written consent
* Patients of childbearing potential and their partners must agree to use an effective form of contraception during the study and for 90 days following last dose of study medication

Exclusion Criteria:

* Patients amenable to a "curative intent" therapeutic approach (re-resection with or without preoperative or postoperative therapy or chemoradiotherapy without surgery are not eligible for this study).
* An active infection or with fever \> 101.00 F within 3 days of first scheduled day of protocol treatment
* Active CNS metastases. Patients with stable CNS disease, who have undergone radiotherapy (or surgery ± radiotherapy) at least 4 weeks prior to planned first protocol treatment and who have been on stable or decreasing dose of corticosteroids for \>2 weeks are eligible
* Prior malignancy within the past 5 years except for curatively treated basal cell carcinoma of the skin, cervical intra-epithelial neoplasia, or localized prostate cancer with a current PSA of \< 1.0 mg/dL on 2 successive evaluations, at least 3 months apart, with most recent evaluation no more than 4 weeks prior to entry.
* Any diagnosis of NSCLC occurring after 5 years of curative therapy (surgery plus adjuvant chemotherapy) for original NSCLC will be considered a second primary rather than a recurrence and will render patient ineligible for this study. An exception will be if both tumors are considered the same after a direct pathologic comparison if both, sponsor and investigator agree.
* Patients that at discretion of the PI have a second primary rather than metastasis are not eligible
* Known hypersensitivity to any of the components of oxaliplatin or pemetrexed.
* Patients receiving concurrent investigational therapy or who have received investigational therapy within 30 days of the first scheduled day of protocol treatment
* Patients who received radiotherapy to more than 33% of their bone marrow or received any radiotherapy within 4 weeks of entry
* Peripheral neuropathy ≥ Grade 2
* Patients pregnant or lactating
* Any other medical condition, including mental illness or substance abuse, deemed likely to interfere with patient's ability to sign informed consent, cooperate and participate in the study, or interfere with interpretation of the results.
* History of allogeneic transplant
* Known history of HIV or Hepatitis B or C infection. Patients with Hepatitis B carrier status only are eligible.

• Tampa, Florida, United States