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Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues

CompletedN/A

Sponsor: University of California, San Francisco

Conditions: Asthma

Countries: United States

The purpose of this study is to investigate mechanisms which cause acute asthma exacerbations by examining blood and airway secretions during an acute onset (sputum or tracheal aspirates). This pilot study is intended to uncover new mechanisms of asthma exacerbation and to generate hypotheses for future study. By collaborating with Genentech, we (scientists at UCSF) plan to incorporate the latest scientific findings into our work to discover and develop new treatments for asthma.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. Male and female subjects aged 18 - 70 years
2. Medical history of asthma
3. Currently experiencing an acute exacerbation of asthma
4. Ability to provide informed consent or have a surrogate provide consent.
5. Ability to provide sputum.

Exclusion Criteria:

1. Cigarette smoking: Subjects must be non-smokers. Non-smokers are defined as subjects who have never smoked or who have not smoked for 1 year and have a total pack-year smoking history \< 10 packs.
2. Pregnant women.

Locations (1)

San Francisco, California, United States