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Intraoperative Versus Postoperative Thymoglobulin in Lung Transplantation

WithdrawnPhase 3

Sponsor: University of California, Los Angeles

Conditions: Lung Transplant

Interventions: thymoglobulin (intraoperative), thymoglobulin (postoperative)

Countries: United States

The purpose of this study is to take a population of lung transplant recipients who meet UCLA criteria for induction chemotherapy with thymoglobulin and prospectively study weather giving the first dose intraoperatively versus postoperatively makes a difference with how patients do during and after lung transplantation.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* On a voluntary basis, all patients eligible for bilateral lung transplantation between the ages of 18-65 years (inclusive)

Exclusion Criteria:

* Have any known allergy to horse or rabbit antithymocyte polyclonal agents
* Have a preoperative platelet count less then 100,000/mm3
* Are recipients of multiple organ transplants (either simultaneous or sequential)
* Are recipients of a single lung transplantation
* Have a contraindication to rabbit antithymocyte globulin based on judgement of the investigators (i.e. bleeding diathesis or overwhelming risk of intense immunosuppression) including the following patients: greater than 65 years of age, prior diagnosis of malignancy (with the exception skin malignancies), underlying suppurative lung disease (i.e. bronchiectasis, cystic fibrosis, etc.).

Locations (1)

Los Angeles, California, United States