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Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA)

CompletedPhase 4

Sponsor: Emory University

Conditions: Diabetic Ketoacidosis

Interventions: insulin glargine+ glulisine, NPH + Regular insulin

Countries: United States

The study is a multicenter, randomized controlled trial to compare the safety and efficacy of insulin analogs and human insulins both during acute intravenous treatment and during the transition to subcutaneous insulin in patients with diabetic ketoacidosis (DKA).

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* All patients admitted to Grady Memorial Hospital who meet diagnosis criteria of DKA and who are willing to participate in the study protocol will be considered candidates for inclusion into the study.
* Diagnostic Criteria for DKA: Blood glucose \> 250 mg/dL, arterial or venous phenol hydroxylase (pH) \< 7.3, serum bicarbonate \< 18 milliequivalent/L, and moderate to severe ketonemia (acetoacetate ≥ 1:4 or βeta-hydroxybutyrate \> 3 mmol).

Exclusion Criteria:

* Hemodynamic instability (MAP \< 50 or patients requiring pressor)
* Significant identifiable medical or surgical illness, including but not limited to: acute myocardial infarction, congestive heart failure; respiratory failure requiring mechanical ventilation; acute or chronic renal insufficiency (serum creatinine \> 3.0 mg/dl); end stage liver failure, and cirrhosis.
* Patients with dementia or persistent altered mental status that would prevent collection of consent form and reliable information.
* Pregnancy

Locations (2)

Atlanta, Georgia, United States
Minneapolis, Minnesota, United States