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Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism

TerminatedNA

Sponsor: Washington University School of Medicine

Conditions: Postmenopausal Syndrome

Interventions: Estrogen, Progesterone, Placebo

Countries: United States

Estrogen and progesterone are two main female sex hormones. When a woman goes through menopause, the body's production of estrogen and progesterone significantly decreases. Recent studies have shown that the breakdown of fatty acids in cardiac muscle is important in maintaining a healthy heart, and that estrogen may enhance this process. Also, cardiovascular disease (CVD) occurs more frequently in postmenopausal women than in premenopausal women. This study will determine in postmenopausal women whether estrogen increases the heart's ability to use fats as energy and whether progesterone decreases this effect.

Eligibility overview

Sex: FEMALE

Age: 55 Years to 75 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Healthy postmenopausal woman
* Body mass index less than 30
* Practices normal eating habits
* Stops hormone replacement therapy at least 6 months prior to study entry

Exclusion Criteria:

* Currently taking hormone replacement therapy
* History of cardiovascular disease
* Family history of coronary artery disease
* Recent history of smoking, high blood pressure, or hyperlipidemia

Locations (1)

St Louis, Missouri, United States