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A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Metastatic Bone Disease.

NCT00478270

WithdrawnPhase 2

Sponsor: Hoffmann-La Roche

Conditions: Pain, Bone Neoplasm, Neoplasm Metastasis

Interventions: ibandronate [Bondronat]

Countries: Greece

This single arm study will assess the efficacy of loading doses of intravenous Bondronat in reducing pain in patients with breast cancer and metastatic bone disease experiencing moderate to severe bone pain. Patients will receive an intravenous infusion of 6mg Bondronat on days 1, 2 and 3. The anticipated time on study treatment is \<3 months, and the target sample size is \<100 individuals.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* adult patients, \>=18 years of age;
* breast cancer;
* bone metastases;
* mean worst pain score \>=4 during 3 day baseline period;
* stable dose of analgesics over a 3 day baseline period;
* adequate renal function.

Exclusion Criteria:

* bisphosphonate treatment within 3 weeks of study enrollment;
* a change in antineoplastic treatment within 6 weeks of study enrollment;
* bone radiation within 2 weeks of study enrollment;
* active infection.

Locations (6)

Alexandroupoli, Greece
Athens, Greece
Haidari, Greece
Pátrai, Greece
Piraeus, Greece
Thessaloniki, Greece