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An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer
An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer

NCT00410761

CompletedPhase 3

Sponsor: Genzyme, a Sanofi Company

Conditions: Thyroid Cancer

Interventions: ZD6474 (Vandetanib)

Countries: United States, Australia, Austria, Belgium, Brazil, Canada, Czechia, Denmark

The purpose of this study is to learn how hereditary or sporadic medullary thyroid cancer patients, treated with ZD6474, react to the drug, what happens to ZD6474 in the human body, about the side effects of ZD6474, and if ZD6474 can decrease or prevent the growth of tumors.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Confirmed diagnosis of unresectable, locally advanced or metastatic hereditary or sporadic Medullary Thyroid Cancer.
* Presence of measurable tumor
* Able to swallow medication

Exclusion Criteria:

* Major surgery within 4 weeks before randomization
* Last dose of prior chemotherapy received less than 4 weeks prior to randomization
* Radiation therapy within the last 4 weeks prior to randomization(with exception of palliative radiotherapy)
* Brain metastases or spinal cord compression, unless treated at least 4 weeks before first dose and stable without steroid treatment for 10 days
* Significant cardiac events
* Previous ZD6474 treatment
Locations (127)
  • Little Rock, Arkansas, United States
  • Little Rock, Arkansas, United States
  • San Francisco, California, United States
  • San Francisco, California, United States
  • Aurora, Colorado, United States
  • Aurora, Colorado, United States
  • New Haven, Connecticut, United States
  • New Haven, Connecticut, United States
  • Jacksonville, Florida, United States
  • Jacksonville, Florida, United States
  • Chicago, Illinois, United States
  • Chicago, Illinois, United States
  • Lexington, Kentucky, United States
  • Lexington, Kentucky, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • Detroit, Michigan, United States
  • Detroit, Michigan, United States
  • Rochester, Minnesota, United States
  • Rochester, Minnesota, United States
  • St Louis, Missouri, United States
  • St Louis, Missouri, United States
  • Cincinnati, Ohio, United States
  • Cincinnati, Ohio, United States
  • Portland, Oregon, United States
  • Portland, Oregon, United States
  • Charleston, South Carolina, United States
  • Charleston, South Carolina, United States
  • Houston, Texas, United States
  • Houston, Texas, United States
  • + 97 more on CT.gov