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ZD1839 With Hypofractionated Radiation Therapy With an Immobilization Device for Advanced Non-Small Cell Lung Cancer

CompletedPhase 1

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

Conditions: Non-Small Cell Lung Carcinoma (NSCLC)

Interventions: ZD1839 (Iressa), Thoracic Radiotherapy

Countries: United States

The purpose of this study is to determine the safety and effectiveness of Iressa when used with a short course of high dose radiation therapy in patients with lung cancer.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Histologically confirmed non small cell lung cancer
* Stage IV needing radiation therapy to control symptoms
* Patients with brain metastases
* Unresectable or medically inoperable

Exclusion Criteria:

* Small cell lung cancer
* Previous thoracic radiation therapy
* Oxygen-dependent patients
* Forced expiratory volume in 1 second (FEV1) less than 1.5
* Patients with active interstitial lung disease
* Patients with underlying lung disease

Locations (1)

Philadelphia, Pennsylvania, United States