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Pregabalin for Abdominal Pain From Adhesions

TerminatedPhase 4

Sponsor: Henry Ford Health System

Conditions: Abdominal Pain, Surgical Adhesions

Interventions: Pregabalin 75 or 150 mg BID for 7 weeks followed by open label pregabalin 150 mg BID for 4 weeks, Placebo first followed by open label pregabalin

Countries: United States

The purpose of this study is to evaluate if pregabalin demonstrates significant reduction in abdominal pain from adhesions.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Must have history of prior surgery and documented adhesions during laparoscopy or open laparotomy within 5 years
* Must have undergone an evaluation to exclude other causes of abdominal pain
* Abdominal pain must be present for greater than three months duration

Exclusion Criteria:

* Patients that are pregnant or breast feeding
* Prior treatment with gabapentin, pregabalin or demonstrated sensitivity to these drugs
* Patients who are immunocompromised
* Patients with significant hepatic or renal insufficiency, or any significant hematologic disorder
* History of illicit alcohol or drug abuse within one year
* Documented serious or unstable medical or psychological condition
* Malignancy within the past 5 years other than in situ squamous cell carcinoma of the skin

Locations (1)

West Bloomfield, Michigan, United States