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A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure
A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure

NCT00303498

CompletedPhase 2

Sponsor: Pfizer

Conditions: Diastolic Heart Failure

Interventions: Sitexsentin sodium, Placebo

Countries: United States, Canada

The aim of this study was to determine whether long-term (≥ 6 months at the target dose) blockade of ETA receptors using sitaxsentan showed functional benefit in subjects with chronic Heart Failure and an Left Ventricular Ejection Fraction ≥50%.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* 18 or older with chronic heart failure and evidence of diastolic dysfunction on echocardiogram, heart imaging, and a minimum exercise tolerance average time of 120 seconds on two treadmill tests within 2 weeks of enrollment

Exclusion Criteria:

* unstable cardiovascular disease within 4 weeks of screening, history of heart attack, cardiac by-pass surgery or percutaneous intervention, stent placement, within 3 months of screening or amyloidosis, hypertrophic obstructive or restrictive cardiomyopathy, or constrictive pericarditis
Locations (52)
  • Birmingham, Alabama, United States
  • Mobile, Alabama, United States
  • Mobile, Alabama, United States
  • Little Rock, Alaska, United States
  • Phoenix, Arizona, United States
  • Tucson, Arizona, United States
  • Tucson, Arizona, United States
  • Little Rock, Arkansas, United States
  • Los Angeles, California, United States
  • Orange, California, United States
  • Sacramento, California, United States
  • San Diego, California, United States
  • New Haven, Connecticut, United States
  • Washington D.C., District of Columbia, United States
  • Orlando, Florida, United States
  • Chicago, Illinois, United States
  • Peoria, Illinois, United States
  • Auburn, Maine, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • Minneapolis, Minnesota, United States
  • St Louis, Missouri, United States
  • St Louis, Missouri, United States
  • Lincoln, Nebraska, United States
  • Manchester, New Hampshire, United States
  • Newark, New Jersey, United States
  • Buffalo, New York, United States
  • New York, New York, United States
  • Troy, New York, United States
  • Charlotte, North Carolina, United States
  • + 22 more on CT.gov