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A Study of Factors That Affect Long-Term Kidney Transplant Function

CompletedN/A

Sponsor: University of Minnesota

Conditions: Kidney Transplant

Countries: United States, Canada

The causes of deterioration of transplanted kidney function are poorly understood. The purpose of this study is to determine the disease processes that cause transplanted kidney dysfunction and loss in patients who received a kidney either recently or over a year prior to entering this study. This study will also identify specific characteristics in kidney transplant recipients that predict whether a kidney transplant will be successful.

Eligibility overview

Sex: ALL

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria for Prospective Cohort:

* Received a kidney transplant within 10 days prior to study entry, on or after 10-01-2005
* Recipient of kidney or simultaneous kidney/pancreas with no additional transplant at the time of the kidney transplant

Inclusion Criteria for Retrospective Cohort:

* Received a kidney transplant before 10-01-2005
* Recipient of kidney or simultaneous kidney/pancreas with no additional transplant at the time of the kidney transplant
* Undergoes a clinically indicated kidney biopsy due to new onset deterioration of function, defined as having an increase in serum creatinine
* The creatinine level on or before 01-01-2006 must be 2 mg/dl or less OR the patient must have developed new onset proteinuria, defined as having a protein/creatinine ratio of 0.4 or more

Locations (7)

Birmingham, Alabama, United States
Iowa City, Iowa, United States
Minneapolis, Minnesota, United States
Minneapolis, Minnesota, United States
Rochester, Minnesota, United States
Edmonton, Alberta, Canada
Winnipeg, Manitoba, Canada