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Liver Transplantation in Patients With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Coinfection

TerminatedPhase 2

Sponsor: ANRS, Emerging Infectious Diseases

Conditions: HIV Infections, Hepatitis C

Interventions: liver transplantation

Countries: France

To show the feasibility of liver transplantation in HCV-HIV coinfected patients. To study the two-year survival after transplantation, the interaction between HCV and HIV after transplantation, the influence of HIV on HCV recurrence after transplantation, the interaction between immunosuppressive and antiretroviral drugs in particular anti-proteases, immunological follow-up and quality of life of these patients

Eligibility overview

Sex: ALL

Age: 18 Years to 69 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Coinfection HIV-HVC
* Indication of liver transplantation for severe hepatopathy with life threatening:repetitive ascitis or infection of ascitis or icterus or decreased of prothrombin index under 50 percent or digestive haemorrhage by portal hypertension uncontrolled

Exclusion Criteria:

* Toxicomania
* Alcohol consumer (over 30g per day)
* AgHBs positive
* hepatocarcinoma over 5 cm or 3 nodules
* CD4 below 200/mm3
* Viral load below 400 cp
* HIV stade C

Locations (1)

Villejuif, France