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Sponsor: UNICANCER
Conditions: Prostate Cancer
Interventions: bicalutamide, Goserelin Acetate, docetaxel, Estramustine phosphate sodium, acetylsalicylic acid
Countries: France
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from producing androgens. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy is more effective with or without chemotherapy in treating prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy with or without docetaxel and estramustine in treating patients who have prostate cancer that is locally advanced or at high risk of relapse.
Sex: MALE
Age: 0 Years to 79 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
DISEASE CHARACTERISTICS: * Histologically confirmed adenocarcinoma of the prostate * Locally advanced disease or at high risk for relapse * No clinically or radiologically suspected metastases * Prior lymphadenectomy required * Meets at least 1 of the following criteria for poor prognosis: * Gleason score greater than 7 * T3 or T4 disease * Prostate-specific antigen greater than 20 ng/mL * N1 disease PATIENT CHARACTERISTICS: Age * Under 80 Performance status * ECOG 0-2 Life expectancy * More than 10 years Hematopoietic * Absolute neutrophil count greater than 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic * AST and ALT no greater than 1.5 times upper limit of normal (ULN) * Bilirubin no greater than ULN Renal * Creatinine less than 1.6 mg/dL OR * Creatinine clearance greater than 60 mL/min Cardiovascular * No uncontrolled or severe cardiovascular disease * No prior thrombosis Pulmonary * No prior pulmonary embolus Other * No active infection * No intolerance to aspirin * No other prior malignancy except basal cell skin cancer * No physical or psychological condition that would preclude study compliance PRIOR CONCURRENT THERAPY: Biologic therapy * No concurrent immunotherapy Chemotherapy * No prior chemotherapy * No other concurrent chemotherapy Endocrine therapy * No prior hormonal therapy * No other concurrent hormonal therapy Radiotherapy * Not specified Surgery * See Disease Characteristics Other * No other concurrent anticancer therapy
- Angers, France
- Bordeaux, France
- Bordeaux, France
- Boulogne-Billancourt, France
- Caen, France
- Cholet, France
- Créteil, France
- Hyères, France
- La Roche-sur-Yon, France
- Lille, France
- Limoges, France
- Lormont, France
- Lyon, France
- Marseille, France
- Marseille, France
- Metz, France
- Metz, France
- Mont-de-Marsan, France
- Montpellier, France
- Montpellier, France
- Nantes, France
- Nice, France
- Paris, France
- Paris, France
- Paris, France
- Paris, France
- Paris, France
- Reims, France
- Rennes, France
- Rodez, France
- + 8 more on CT.gov