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Antibiotic Treatment of Gulf War Veterans' Illnesses
Antibiotic Treatment of Gulf War Veterans' Illnesses

NCT00007735

CompletedPhase 3

Sponsor: US Department of Veterans Affairs

Conditions: Persian Gulf Syndrome, Mycoplasma Infections

Interventions: Doxycycline (200mg/day) or Placebo

Countries: United States, Puerto Rico

In 1990 and 1991, the U.S. deployed approximately 700,000 troops to the Persian Gulf to liberate Kuwait from Iraqi occupation. While there were few casualties associated with the Gulf War, many individuals returned from this conflict with unexplained symptoms and illnesses. This constellation of symptoms has been termed Gulf War Veterans' Illnesses (GWI). Although several explanations have been offered as to the cause of GWI, none of the putative etiologic agents or conditions is currently supported by sufficient evidence. One explanation that has received fairly widespread attention is systemic Mycoplasma fermentans infection. It is the purpose of this study to determine if antibiotic treatment directed against Mycoplasma species (i.e. doxycycline) will improve functioning and symptoms in deployed Gulf War veterans with GWI.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria
All veterans deployed to the Gulf War between August, 1990 and August, 1991 having at least two of the following symptoms: Fatigue, musculoskeletal pain or neurocognitive dysfunction. Mycoplasma positive
Locations (27)
  • Birmingham, Alabama, United States
  • San Diego, California, United States
  • Washington D.C., District of Columbia, United States
  • Augusta, Georgia, United States
  • Hines, Illinois, United States
  • New Orleans, Louisiana, United States
  • Boston, Massachusetts, United States
  • Omaha, Nebraska, United States
  • Manchester, New Hampshire, United States
  • East Orange, New Jersey, United States
  • Albuquerque, New Mexico, United States
  • Albany, New York, United States
  • Brooklyn, New York, United States
  • The Bronx, New York, United States
  • Durham, North Carolina, United States
  • Fargo, North Dakota, United States
  • Kettering, Ohio, United States
  • Oklahoma City, Oklahoma, United States
  • Philadelphia, Pennsylvania, United States
  • Providence, Rhode Island, United States
  • Charleston, South Carolina, United States
  • Nashville, Tennessee, United States
  • Houston, Texas, United States
  • White River Junction, Vermont, United States
  • Richmond, Virginia, United States
  • Milwaukee, Wisconsin, United States
  • San Juan, Puerto Rico