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Results for “Roche”

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824 in Participants With Angelman Syndrome (AS)Completed
NCT04428281Phase 1Updated Aug 24, 2025
Sponsor: Hoffmann-La Roche
Angelman Syndrome
United States, Italy, Netherlands, Spain
Trial of Mosunetuzumab (BTCT4465A) as Consolidation Therapy in Participants With Diffuse Large B-Cell Lymphoma Following First-Line Immunochemotherapy and as Monotherapy or in Combination With Polatuzumab Vedotin in Elderly/Unfit Participants With Previously Untreated Diffuse Large B-Cell LymphomaCompleted
NCT03677154Phase 1, Phase 2Updated Aug 21, 2025
Sponsor: Hoffmann-La Roche
Diffuse Large B-cell Lymphoma
United States, Israel, Poland, South Korea, Spain +1 more
Best Practice Study of Diabetes Type 2 Management in Primary Care in SwitzerlandCompleted
NCT04216875N/AUpdated Aug 20, 2025
Sponsor: QualiCCare
Diabetes Mellitus, Type 2 · Primary Care
Switzerland
A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid TumorsCompleted
NCT03708328Phase 1Updated Aug 20, 2025
Sponsor: Hoffmann-La Roche
Solid Tumors · Metastatic Melanoma · Non-small Cell Lung Cancer (NSCLC) · Small Cell Lung Cancer (SCLC)
United States, Denmark, France, New Zealand, South Korea +1 more
A Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC)Terminated
NCT04740918Phase 3Updated Aug 8, 2025
Sponsor: Hoffmann-La Roche
Metastatic Breast Cancer
United States, Australia, Brazil, Canada, China +14 more
Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium AssessmentCompleted
NCT05411991Phase 4Updated Aug 8, 2025
Sponsor: Vrije Universiteit Brussel
Acute Heart Failure · Diuretics Drug Reactions
Belgium
Real World Study Using Comprehensive Genomic Data on the Next Treatment Decision Making in Metastatic Breast CancerActive Not Recruiting
NCT04497285N/AUpdated Aug 6, 2025
Sponsor: SOLTI Breast Cancer Research Group
Metastatic Breast Cancer
Spain
PEPPI Study: Identification of Women at Risk for Placental DysfunctionRecruiting
NCT06115122N/AUpdated Aug 5, 2025
Sponsor: Oulu University Hospital
Pre-Eclampsia · Intrauterine Growth Restriction · Polycystic Ovary Syndrome · Iron-deficiency
Finland
Phase 2 Study Assessing Secured Access to Vemurafenib for Patients With Tumors Harboring BRAF Genomic AlterationsActive Not Recruiting
NCT02304809Phase 2Updated Aug 1, 2025
Sponsor: UNICANCER
Solid Tumors · Hematologic Cancers · Metastatic Cancers
France
Point of Care Polymerase Chain Reaction (PCR) Diagnostics of Respiratory Tract Infections in General PracticeActive Not Recruiting
NCT06120153NAUpdated Jul 31, 2025
Sponsor: University of Southern Denmark
Respiratory Tract Infections
Denmark
Study of the Pharmacokinetic Action of Amantadine and Ribavirin in Chronic Hepatitis C. CINAMCompleted
NCT00199719Phase 2Updated Jul 30, 2025
Sponsor: University Hospital, Limoges
Chronic Hepatitis C
France
Study of Atezolizumab + FLOT vs. FLOT Alone in Patients With GC/GEJ and High Immune ResponsivenessActive Not Recruiting
NCT03421288Phase 2Updated Jul 25, 2025
Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Gastric Cancer · Gastroesophageal Junction Adenocarcinoma
Germany, Switzerland
ProTarget - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic ProfilingRecruiting
NCT04341181Phase 2Updated Jul 25, 2025
Sponsor: Ulrik Lassen
Cancer · Tumors · Neoplasms · Neoplasia
Denmark
A Trial of Obinutuzumab,GDC-0199 Plus Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma PatientsCompleted
NCT02558816Phase 1, Phase 2Updated Jul 24, 2025
Sponsor: Nantes University Hospital
Mantle Cell Lymphoma
France, United Kingdom
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)Completed
NCT03823287Phase 3Updated Jul 23, 2025
Sponsor: Hoffmann-La Roche
Wet Macular Degeneration
United States, Canada, Germany, Hungary, Israel +10 more
French Clinical Datbase of Melanoma Patients (RIC-Mel)Recruiting
NCT03315468N/AUpdated Jul 22, 2025
Sponsor: Nantes University Hospital
Melanoma (Skin)
France
A Study of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy in Patients With HER2-Positive Breast Cancer Who Have Residual Tumor in the Breast or Axillary Lymph Nodes Following Preoperative Therapy (KATHERINE)Completed
NCT01772472Phase 3Updated Jul 22, 2025
Sponsor: Hoffmann-La Roche
Breast Cancer
United States, Argentina, Austria, Belgium, Brazil +23 more
A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced MelanomaCompleted
NCT02908672Phase 3Updated Jul 20, 2025
Sponsor: Hoffmann-La Roche
Melanoma
United States, Australia, Austria, Belgium, Brazil +15 more
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)Completed
NCT05116202Phase 1, Phase 2Updated Jul 18, 2025
Sponsor: Hoffmann-La Roche
Melanoma
United States, Australia, France, Italy, Spain
Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290 In Combination With Cibisatamab With Obinutuzumab Pre-TreatmentCompleted
NCT04826003Phase 1Updated Jul 14, 2025
Sponsor: Hoffmann-La Roche
Metastatic Colorectal Cancer
Denmark, Netherlands, South Korea, Spain, United Kingdom
A Study Evaluating Safety, Tolerability, and Clinical Activity of Forimtamig-Based Treatment Combinations in Participants With Relapsed or Refractory Multiple MyelomaCompleted
NCT06055075Phase 1, Phase 2Updated Jul 14, 2025
Sponsor: Hoffmann-La Roche
Relapsed or Refractory Multiple Myeloma
Australia, Canada, Italy, New Zealand, South Korea +1 more
Peg-interferon for Inactive Chronic Hepatitis B CarriersCompleted
NCT02992704Phase 2, Phase 3Updated Jul 14, 2025
Sponsor: Seng Gee Lim
Chronic Hepatitis, B Virus · Carrier of Viral Hepatitis Type B
Singapore
Performance Study of the Cobas® BV/CV Test on Samples From Participants With and Without Symptoms of Bacterial Vaginosis and Candida VaginitisCompleted
NCT06975436N/AUpdated Jul 14, 2025
Sponsor: Hoffmann-La Roche
Bacterial Vaginosis · Candida Vaginitis
United States, Bulgaria, Switzerland
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)Completed
NCT03823300Phase 3Updated Jul 11, 2025
Sponsor: Hoffmann-La Roche
Wet Macular Degeneration
United States, Argentina, Australia, Austria, Brazil +16 more
A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)Completed
NCT03622580Phase 3Updated Jul 11, 2025
Sponsor: Hoffmann-La Roche
Diabetic Macular Edema
United States, Austria, Bulgaria, France, Germany +11 more

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