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Results for “Roche”

Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)Completed
NCT00120367Phase 2Updated Apr 2, 2026
Sponsor: French National Agency for Research on AIDS and Viral Hepatitis
Leukoencephalopathy, Progressive Multifocal · HIV Infections
France
Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A ParticipantsCompleted
NCT03315455Phase 3Updated Apr 1, 2026
Sponsor: Hoffmann-La Roche
Hemophilia A
China, Hong Kong, Malaysia, Thailand
Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)Recruiting
NCT03297606Phase 2Updated Mar 27, 2026
Sponsor: Canadian Cancer Trials Group
Lymphoma, Non-Hodgkin · Multiple Myeloma · Advanced Solid Tumors
Canada
A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the EsophagusCompleted
NCT04785820Phase 2Updated Mar 27, 2026
Sponsor: Hoffmann-La Roche
Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Argentina, Brazil, Czechia, Denmark, France +13 more
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following CystectomyActive Not Recruiting
NCT04660344Phase 3Updated Mar 27, 2026
Sponsor: Hoffmann-La Roche
Muscle-invasive Bladder Cancer
United States, Argentina, Belgium, Brazil, China +19 more
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)Active Not Recruiting
NCT04958265Phase 3Updated Mar 27, 2026
Sponsor: Hoffmann-La Roche
Atypical Hemolytic Uremic Syndrome
United States, Belgium, Brazil, Canada, China +5 more
Enabling Genomic Testing in Cancer of Unknown PrimaryRecruiting
NCT06695494N/AUpdated Mar 25, 2026
Sponsor: The Christie NHS Foundation Trust
Cancer of Unknown Primary · Neoplasm, Unknown Primary
United Kingdom
Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal MetastasesActive Not Recruiting
NCT02758951Phase 2, Phase 3Updated Mar 24, 2026
Sponsor: Koen Rovers
Colorectal Neoplasm · Colorectal Cancer · Colorectal Neoplasms Malignant · Colorectal Carcinoma
Belgium, Netherlands
Targeting PD-L1 and TIGIT in Tumors With Tertiary Lymphoid StructuresWithdrawn
NCT06713798Phase 2Updated Mar 23, 2026
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Metastatic Cancer Lung · Advanced Lung Cancer · CBNPC Cancer
Easing Scan Anxiety in Pediatric Oncology Caregivers Through Meditation-based ProgramsRecruiting
NCT07420101NAUpdated Mar 19, 2026
Sponsor: Kimberley Roche
Caregiver Anxiety · Caregiver Anxiety Related to Cancer Imaging · Pediatric Oncology
United States
A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor TreatmentTerminated
NCT04338269Phase 3Updated Mar 19, 2026
Sponsor: Hoffmann-La Roche
Carcinoma, Renal Cell
United States, Argentina, Australia, Canada, Denmark +10 more
Spinal Cord Stimulation in Spinal Muscular AtrophyCompleted
NCT05430113NAUpdated Mar 16, 2026
Sponsor: Marco Capogrosso
Spinal Muscular Atrophy Type 3 · Spinal Muscular Atrophy Type 4
United States
Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer PatientsCompleted
NCT04253561Phase 1Updated Mar 16, 2026
Sponsor: SOLTI Breast Cancer Research Group
Metastatic Breast Cancer
Spain
A Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Participants With Metastatic and/or Recurrent PD-L1-Positive Cervical CancerCompleted
NCT04300647Phase 2Updated Mar 12, 2026
Sponsor: Hoffmann-La Roche
Cervical Cancer
United States, Australia, Brazil, Canada, Costa Rica +12 more
Use of Inertial Units in Patient With Multiple Sclerosis (IMUSEP)Completed
NCT06634225N/AUpdated Mar 12, 2026
Sponsor: Lille Catholic University
Multiple Sclerosis · Medical Device · Coordination and Balance Disturbances
France
A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung CancerTerminated
NCT04832854Phase 2Updated Mar 11, 2026
Sponsor: Hoffmann-La Roche
Non-Small Cell Lung Cancer (NSCLC)
United States, Australia, South Korea, Spain, Switzerland
DreaMS - Validation Study 1Active Not Recruiting
NCT05009160N/AUpdated Mar 10, 2026
Sponsor: Research Center for Clinical Neuroimmunology and Neuroscience Basel
Multiple Sclerosis
Switzerland
Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung AdenocarcinomaActive Not Recruiting
NCT05689671Phase 4Updated Mar 10, 2026
Sponsor: Nikolaj Frost MD
Non-Small Cell Lung Cancer Metastatic
Germany
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple SclerosisRecruiting
NCT07426991N/AUpdated Mar 6, 2026
Sponsor: Heinrich-Heine University, Duesseldorf
Multiple Sclerosis · Remitting-Relapsing Multiple Sclerosis · Primary Progressive Multiple Sclerosis · Secondary Progress Multiple Sclerosis
Germany
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)Active Not Recruiting
NCT04563338Phase 2Updated Mar 5, 2026
Sponsor: University Health Network, Toronto
Hepatocellular Carcinoma · Non-small Cell Lung Cancer Metastatic · Liver Metastases
Canada
Impact of Catheter Ablation on ABC Risk ScoresCompleted
NCT05635864N/AUpdated Mar 5, 2026
Sponsor: Hannover Medical School
Atrial Fibrillation · Atrial Flutter · Stroke · Bleeding
Germany
A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)Terminated
NCT04222972Phase 3Updated Mar 5, 2026
Sponsor: Hoffmann-La Roche
RET-fusion Non Small Cell Lung Cancer · Lung Neoplasm · Carcinoma, Non-Small-Cell Lung · Respiratory Tract Neoplasms
Argentina, Australia, Belgium, Brazil, Costa Rica +17 more
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative TherapyActive Not Recruiting
NCT04873362Phase 3Updated Mar 4, 2026
Sponsor: Hoffmann-La Roche
Breast Cancer
United States, Australia, Austria, Belgium, Brazil +27 more
A Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine And Rituximab (BR) in FIT Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without DEL (17P) or TP53 MutationCompleted
NCT04285567Phase 3Updated Mar 3, 2026
Sponsor: Hoffmann-La Roche
Chronic Lymphocytic Leukemia (CLL)
United States, Australia, France, Italy, Spain
A Study to Evaluate Crovalimab in People With Antiphospholipid Syndrome (APS)Withdrawn
NCT07172022Phase 2Updated Mar 2, 2026
Sponsor: Hoffmann-La Roche
Antiphospholipid Syndrome

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