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Results for “Merck”

Neo-adjuvant Pembrolizumab as an Alternative Treatment for MMRd Uterine CancerActive Not Recruiting
NCT06180733Phase 2Updated May 1, 2026
Sponsor: University Medical Center Groningen
Endometrial Cancer
Netherlands
Immunogenicity of HPV Vaccine in Transplant Recipients.Active Not Recruiting
NCT05557370Phase 4Updated May 1, 2026
Sponsor: Medical College of Wisconsin
Chronic Kidney Diseases · Kidney Transplant
United States
Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPDActive Not Recruiting
NCT05612035Phase 2Updated May 1, 2026
Sponsor: Merck Sharp & Dohme LLC
Pulmonary Hypertension · Chronic Obstructive Pulmonary Disease
United States, Argentina, Australia, Austria, Belgium +14 more
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)Active Not Recruiting
NCT04241185Phase 3Updated May 1, 2026
Sponsor: Merck Sharp & Dohme LLC
Urinary Bladder Neoplasms
United States, Australia, Chile, Czechia, Denmark +20 more
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)Active Not Recruiting
NCT03711032Phase 3Updated May 1, 2026
Sponsor: Merck Sharp & Dohme LLC
High-risk Non-muscle Invasive Bladder Cancer
United States, Australia, Austria, Belgium, Brazil +25 more
PI Pembro in Combination With Stereotactic Body Radiotherapy for Liver Metastatic Colorectal CancerCompleted
NCT02837263Phase 1Updated May 1, 2026
Sponsor: University of Wisconsin, Madison
Colorectal Cancer · Colorectal Adenocarcinoma · Stage IVA Colorectal Cancer · Stage IVB Colorectal Cancer
United States
To Determine the Effect of CYP Induction Following Administration of Nirogacestat in Healthy Adult Male ParticipantsCompleted
NCT07259330Phase 1Updated May 1, 2026
Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Healthy
Netherlands
Effect of Renal Impairment on Enpatoran PharmacokineticsCompleted
NCT06589713Phase 1Updated May 1, 2026
Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Renal Impairment
Germany
National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in ChildrenRecruiting
NCT00414115N/AUpdated May 1, 2026
Sponsor: University of British Columbia
Adverse Drug Reaction (ADR)
Canada
A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.Completed
NCT05004350Phase 2Updated Apr 30, 2026
Sponsor: Pierre Fabre Medicament
BRAF V600E · Metastatic Colorectal Cancer
China
A Study of Nemtabrutinib (MK-1026) in China Participants With Relapsed or Refractory Hematologic Malignancies (MK-1026-005)Active Not Recruiting
NCT05347225Phase 1Updated Apr 30, 2026
Sponsor: Merck Sharp & Dohme LLC
Hematological Malignancies
China
A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With PembrolizumabActive Not Recruiting
NCT05378425Phase 1Updated Apr 30, 2026
Sponsor: Nectin Therapeutics Ltd
Cancer · Tumor, Solid · Advanced Solid Tumor · Metastatic Cancer
United States, Israel, Poland
Safety and Efficacy Study of GEN1046 as a Single Agent or in Combination With Pembrolizumab for Treatment of Recurrent (Non-small Cell) Lung CancerActive Not Recruiting
NCT05117242Phase 2Updated Apr 30, 2026
Sponsor: Genmab
Non Small Cell Lung Cancer Metastatic
United States, France, Germany, Italy, Netherlands +4 more
Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma PatientsCompleted
NCT02632344Phase 2Updated Apr 30, 2026
Sponsor: Massachusetts General Hospital
Recurrent Respiratory Papillomatosis
United States
Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People With HIV-1Active Not Recruiting
NCT06630286Phase 3Updated Apr 30, 2026
Sponsor: Gilead Sciences
HIV-1-infection
United States, Argentina, Australia, Canada, France +7 more
An Active-Controlled Early Phase Study of Elpipodect (MK-8189) in Adults With Schizophrenia (MK-8189-005)Completed
NCT03055338Phase 2Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Schizophrenia, Acute Episode
United States
Safety, Tolerability, and Pharmacokinetics Study of Elpipodect (MK-8189) in Participants With Schizophrenia and Healthy Participants (MK-8189-011)Completed
NCT04506905Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Schizophrenia
United States
Elpipodect (MK-8189) Safety and Tolerability in Participants With Alzheimer's Disease With or Without Symptoms of Agitation-Aggression and/or Psychosis (MK-8189-017)Completed
NCT05227118Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Alzheimer's Disease
United States
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)Completed
NCT04191096Phase 3Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Metastatic Hormone-Sensitive Prostate Cancer
United States, Australia, Austria, Brazil, Canada +24 more
Elpipodect (MK-8189) Multiple Dose Study in Healthy Volunteers and Schizophrenia Participants (MK-8189-003)Completed
NCT02181803Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Schizophrenia
Clinical Antenatal Randomised Study to CharactErise Key Roles of TetrahydroFOLate in HyperTensive PregnanciesRecruiting
NCT05434195NAUpdated Apr 29, 2026
Sponsor: University of Oxford
Pre-Eclampsia · Pregnancy Induced Hypertension · Pregnancy Related
United Kingdom
A Study to Investigate the Influence of Hepatic Impairment on Elpipodect (MK-8189) Treatment (MK-8189-012)Completed
NCT04676425Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Hepatic Impairment
United States
A Study To Evaluate The Effect Of A Supratherapeutic Dose Of Elpipodect (MK-8189) On The QTc Interval In Participants With Schizophrenia (MK-8189-019)Completed
NCT05893862Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Schizophrenia
United States
A Study of Elpipodect (MK-8189) in Participants With Schizophrenia (MK-8189-014)Completed
NCT05406440Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Schizophrenia
United States
A Study of Elpipodect (MK-8189) in Participants With Bipolar I Disorder (MK-8189-020)Completed
NCT06273774Phase 1Updated Apr 29, 2026
Sponsor: Merck Sharp & Dohme LLC
Bipolar I Disorder
United States

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